Can I take Lanzoprole and Sertraline together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking lansoprazole and sertraline together can increase the amount of sertraline in your bloodstream. This may increase the risk of side effects such as feeling sick, diarrhoea, tremors, or feeling restless. In rare cases, it could lead to a serious condition called serotonin syndrome or affect your heart rhythm.
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Why this happens
Lansoprazole can slow down the liver enzymes (specifically CYP2C19) that are responsible for breaking down sertraline. Because the sertraline is broken down more slowly, it builds up in your body.
What you should do
You can take these medicines together, but you should be aware of increased side effects. If you notice any unusual symptoms like extreme agitation, a very fast heartbeat, or muscle stiffness, contact your doctor. Your doctor may choose to adjust your sertraline dose if you need to take lansoprazole long-term.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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