Can I take Lipitor and Mirtazapine together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no significant interaction between Lipitor (atorvastatin) and mirtazapine. It is generally considered safe to take these two medications together.
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Why this happens
Lipitor and mirtazapine are processed by different pathways in the liver. Lipitor is primarily broken down by an enzyme called CYP3A4, while mirtazapine is processed by several different enzymes (CYP2D6, CYP1A2, and CYP3A4). Because mirtazapine does not strongly block or speed up the enzymes that Lipitor relies on, it does not significantly change the levels of Lipitor in your blood.
What you should do
You can take these medicines together as prescribed by your doctor. As with any statin (like Lipitor), you should always report any unexplained muscle pain, tenderness, or weakness to your doctor, but this risk is not increased by taking mirtazapine.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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