Can I take Lixiana and Zomorph together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking Lixiana (edoxaban) and Zomorph (morphine) together may increase the risk of bleeding, particularly in the stomach or intestines. Additionally, Zomorph can slow down the movement of your digestive system, which might slightly change how Lixiana is absorbed, though the increased bleeding risk is the primary concern.
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Why this happens
Lixiana is an anticoagulant (blood thinner) that prevents clots. Zomorph is an opioid painkiller. While they work differently, opioids can sometimes increase the risk of gastrointestinal bleeding when used with blood thinners. Furthermore, Zomorph slows down the gut (gastric emptying), which can affect how quickly other medicines enter the bloodstream.
What you should do
Use this combination with caution. You should monitor yourself closely for any signs of unusual bleeding, such as easy bruising, nosebleeds, bleeding gums, or dark, tarry stools. If you experience severe dizziness, coughing up blood, or persistent stomach pain, contact your doctor immediately. Ensure your doctor is aware you are taking both medications so they can monitor your treatment.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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