Can I take Omeprazol and Paracetamol together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no significant interaction between omeprazole and paracetamol. It is generally safe to take these two medicines together.
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Why this happens
Omeprazole reduces stomach acid, while paracetamol is mainly absorbed in the small intestine. While omeprazole can slightly change how quickly the stomach empties, studies show this does not have a meaningful effect on how well paracetamol works or its safety levels in the body. They are processed by different enzymes in the liver.
What you should do
You can take these medicines together as prescribed or according to the packaging instructions. You do not need to space them apart. If you find that your pain is not being controlled or if you develop new symptoms, speak with your pharmacist or GP.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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