Can I take Aspirin and Nustendi together?
Drug interaction guide
Originally published 24 Jan 2026
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Taking aspirin with Nustendi (which contains bempedoic acid and ezetimibe) may slightly increase the levels of bempedoic acid in your blood. Additionally, if you are taking high doses of aspirin (over 325mg daily), there is a theoretical risk that it could interfere with how bempedoic acid works to lower your cholesterol.
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Why this happens
Aspirin and bempedoic acid (one of the active ingredients in Nustendi) are both processed by the same pathway in the kidneys (OAT3 transporter). Aspirin may compete with bempedoic acid, potentially slowing down its removal from the body or blocking its effectiveness at very high doses.
What you should do
For most people taking low-dose 'baby' aspirin (75mg to 100mg) for heart protection, this interaction is unlikely to be clinically significant. You can continue taking both, but ensure your doctor knows you are using them. If you take high-dose aspirin for pain or inflammation, consult your doctor as they may prefer an alternative painkiller.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
24 janvier 2026 | Publié à l'origine
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