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Les probiotiques peuvent-ils traiter l'obésité et le diabète ?

Il peut être nécessaire d'apporter des changements importants à votre mode de vie pour prendre soin de votre santé lorsque vous souffrez d'obésité ou de diabète. Mais que se passerait-il si les probiotiques pouvaient soutenir votre parcours vers une perte de poids saine, réduire les niveaux de cholestérol et améliorer la sensibilité à l'insuline ainsi que la gestion de la glycémie ?

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Que sont les probiotiques ?

Probiotics are good (beneficial) bacteria that you can consume to balance out the bad (unbeneficial) bacteria in your gut. This natural balance of good and bad bacteria plays a huge role in your overall health - and scientists have discovered an important link between good bacteria, obesity, and diabetes.

With the help of Dr Sharmila Devi, we explore the latest emerging evidence for des probiotiques as a treatment for both obesity and diabetes - two conditions that are often closely related.

Probiotics may help people with l'obésité to lose weight and reduce associated health problems.

Dr Sharmila Devi, a dietitian nutritionist explains that people with obesity have different gut bacteria compared to people who don't.

She says: "This can lead to inflammation, which is a common complication of obesity."

Having long-term inflammation damages cells and can cause all sorts of serious issues, including diabète de type 2, une maladie cardiaque, and breast ou colon cancer.

The inflammation can partly be helped by taking probiotics and making other changes to your diet. Probiotics may also help you to reverse obesity and reach a healthy weight with other lifestyle measures.

According to Devi, they may work in several ways.

Probiotics may prevent liver fat build-up

Fat is normally stored in the liver, and too much can raise cholesterol. However, probiotics have been shown to stop fat accumulating here, decrease liver weight and blood fats.

Devi says: "This is important because a build-up of fat in the liver can lead to stéatose hépatique non alcoolique (NAFLD) - a common complication of obesity that can lead to serious maladie du foie, AVC, and crises cardiaques."

The new name for NAFLD is metabolic dysfunction-associated steatotic liver disease (MASLD).

Probiotics may help weight loss

By helping to reduce liver weight, probiotics can also reduce your overall body weight and fat volume, when supporting a healthy diet.

Dans une étude portant sur des femmes obèses souffrant de dépendance alimentaire, celles qui ont pris des suppléments probiotiques ont perdu beaucoup plus de poids que celles qui ne l'ont pas fait. Les deux groupes ont également suivi un régime hypocalorique en même temps. L'étude a également révélé que ces probiotiques étaient capables de réguler les hormones responsables de la sensation de satiété1.

Probiotics may lower cholesterol

"Studies have also shown that probiotics can help reduce cholestérol levels," says Dr Devi.

One study revealed that certain probiotic strains absorb cholesterol into their cells, effectively removing it from the bloodstream.

Obesity is closely linked to having high cholesterol - although there are other causes of high cholesterol, including genetics. This can cause a build-up of plaque in your blood vessels, which restricts blood flow to your heart. This is why having high cholesterol puts you in danger of heart attacks, une maladie cardiaque, and stroke.

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Obesity and type 2 diabetes are closely connected - the former increasing your chances of developing the latter. They also share many of the same health complications, including l'hypertension artérielle, heart disease, and other heart-related problems.

Probiotics are already being used to treat type 2 diabetes, especially the bacteria strains called Lactobacillus and Bifidobacterium.

Probiotics improve insulin sensitivity

"Probiotics have been shown to be effective in the treatment of diabetes because they can help improve insulin sensitivity, which is important for people with diabetes," says Devi.

Insulin is a hormone released by your body to help the sugar in your blood pass to your cells. By increasing your sensitivity to insulin, you can lower your blood sugar levels and the associated hazards, which include damage to your eyes, nerves, and kidneys.

By reducing the buildup of fat in your liver, probiotics can reduce insulin resistance because less insulin is used up for synthesising fatty acids.

Probiotics reduce inflammation

Devi also points out that probiotics can help reduce long-term inflammation in the body, where your immune system triggers internal swelling throughout your body, leading to cell damage.

Inflammation is another common outcome of diabetes. Diabète de type 1 is more related to how your immune system works, which directly influences inflammation processes in the body. In contrast, type 2 diabetes is often related to lifestyle factors, such as having a pro-inflammatory diet or having obesity, which can trigger inflammation.

For this reason, anti-inflammatory diets are also being considered as a treatment for type 2 diabetes, alongside probiotic supplementation for type 1 and type 2.

Probiotics are found in many fermented foods, including natural yoghurt, kefir, kimchi and sauerkraut. They are also widely available as supplements, in the form of tablets, powders, and liquids - here's how to look for a quality probiotic supplement.

Devi describes the evidence on probiotics for the treatment of obesity and diabetes as promising. However, she warns that there are still some knowledge gaps to be addressed.

"We don't yet know the optimal dose of probiotics you should take daily to treat obesity and diabetes," she says. "We also need more research to fully understand the long-term effects of probiotic supplements on human health."

What we do know is that consuming probiotic supplements is generally considered safe for weeks and months at a time.

You cannot effectively treat obesity and type 2 diabetes without a healthy diet and active lifestyle. There's no evidence that probiotics have a beneficial effect if your diet is poor. The takeaway? You may want to try probiotics to support your health, as long as they are an addition to - and not a replacement for - the healthy lifestyle tactics recommended by your doctor.

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  1. Narmaki et al: The combined effects of probiotics and restricted calorie diet on the anthropometric indices, eating behavior, and hormone levels of obese women with food addiction: a randomized clinical trial.

Need weight loss treatment?
Complete a simple online consultation through Patient.info, available 24/7
All consultations are reviewed by UK registered clinicians, powered by Evaro - a UK regulated healthcare service supporting over 2 million patients. Treatments can often be delivered next day.

About the author

Author image

Amberley Davis

Senior writer

BA (Hons), CPD

Amberley is a senior writer with Patient and has written extensively on a range of health and wellbeing topics.

About the reviewerView full bio

Author image

Dr Colin Tidy, MRCGP

Médecin généraliste, Auteur médical

MBBS, MRCGP, MRCP (Paediatrics), DCH

Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.

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