Can I take 1.25 and Omeprazole together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Omeprazole can significantly reduce the amount of 1.25 (calcitriol) that your body absorbs. This may lead to lower levels of calcium in your blood, which can cause symptoms like muscle cramps, tingling in the hands or feet, or weakened bones over time.
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Why this happens
Calcitriol (1.25-dihydroxyvitamin D3) requires a certain level of stomach acid to be absorbed effectively. Omeprazole works by reducing stomach acid, which makes it harder for your body to take in the calcitriol. Additionally, long-term use of omeprazole can interfere with how the body manages calcium levels.
What you should do
Back to contentsSpeak to your doctor before taking these together. They may need to monitor your blood calcium levels more closely or adjust your dose of calcitriol. If you experience any unusual muscle twitching or cramps, contact your healthcare provider.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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