Can I take 1.5mg and Atorvastatin together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Taking colchicine and atorvastatin together can increase the risk of muscle problems. This can range from mild muscle aches and weakness to a rare but very serious condition called rhabdomyolysis, where muscle tissue breaks down and can cause kidney damage.
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Why this happens
Both drugs are processed by the same enzyme in the liver (CYP3A4) and the same transport protein (P-gp). When taken together, atorvastatin can slow down the removal of colchicine from your body, and both drugs have the potential to cause muscle toxicity independently. This 'double hit' increases the risk of side effects.
What you should do
Back to contentsYou must speak to your doctor before taking these together. If your doctor decides you need both, they may prescribe a lower dose of one or both medicines. Seek medical help immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if you also have a fever or dark-coloured urine.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published

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