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Can I take 100 and Iron together?

Drug interaction guide

Taking iron supplements with levothyroxine (T4) can significantly reduce the amount of thyroid hormone your body absorbs. This can lead to an underactive thyroid, causing symptoms like tiredness, weight gain, and feeling cold.

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Why this happens

Iron binds to the levothyroxine in your stomach or gut, forming a complex that is too large for your body to absorb into the bloodstream.

You must separate these two medications by at least 4 hours. It is usually best to take your levothyroxine first thing in the morning on an empty stomach, and wait until at least 4 hours later to take your iron supplement.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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