Can I take 100 and Omeprazole together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Omeprazole can significantly reduce the amount of 100 (posaconazole) that your body absorbs. This means the antifungal medicine may not work well enough to treat or prevent your infection.
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Why this happens
Posaconazole (100) needs a highly acidic environment in the stomach to dissolve properly so it can be absorbed into the bloodstream. Omeprazole works by reducing stomach acid, which prevents the posaconazole from dissolving and entering your system.
What you should do
Back to contentsYou should avoid taking omeprazole while you are taking posaconazole (100) tablets or oral suspension. If you need treatment for acid reflux, speak to your doctor; they may suggest an alternative or monitor you very closely. Do not stop taking your prescribed medicines without consulting your healthcare provider first.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking fluoxetine with Abilify (aripiprazole) can significantly increase the amount of Abilify in your bloodstream. This makes you much more likely to experience side effects such as extreme sleepiness, restlessness (feeling like you cannot sit still), uncontrollable body movements (tremors or twitching), and dizziness. There is also a small but serious risk of a heart rhythm problem called QT prolongation.
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Can I take Acetaminophen and Trazodone together?
Taking paracetamol (acetaminophen) and trazodone together is generally considered safe, but there is a small risk of increased side effects. Both substances are processed by the liver, and in some cases, taking them together might slightly increase the levels of trazodone in your blood. This could make you feel more drowsy or dizzy than usual. Additionally, both medications can occasionally affect your liver function, so using them together over a long period requires caution.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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