Can I take 15 and Levodopa together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking vitamin B6 (pyridoxine) can make levodopa much less effective at treating Parkinson's disease symptoms. This means your tremors, stiffness, or movement problems could get worse.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Vitamin B6 speeds up the process of breaking down levodopa in the body before it has a chance to reach the brain. If the medicine is broken down too early, it cannot work properly to manage your symptoms.
What you should do
Back to contentsDo not take vitamin B6 supplements (including multivitamins containing B6) while taking levodopa unless specifically told to by your doctor. If you are taking a combination tablet that contains both levodopa and carbidopa (such as Sinemet), this interaction is less likely to happen, but you should still check with your pharmacist or doctor before starting any new supplements.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Atorvastatin and Magnesium together?
Taking magnesium antacids at the same time as atorvastatin can lower the amount of the statin medicine that your body absorbs. This might make your cholesterol treatment less effective.

Treatment and medication
Can I take Alodipine and Bisoprolol together?
Taking amlodipine and bisoprolol together can cause your blood pressure to drop lower than if you took either medicine alone. It can also significantly slow down your heart rate. This may make you feel dizzy, lightheaded, faint, or unusually tired.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.