Can I take 40 and Sertraline together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking alcohol with sertraline can make you feel much more drowsy, dizzy, or lightheaded than usual. It can also affect your coordination and judgement. Additionally, alcohol can make the symptoms of depression or anxiety worse, which may interfere with how well sertraline works for you.
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Why this happens
Both alcohol and sertraline affect the central nervous system. When taken together, they have an 'additive' effect, meaning they increase each other's sedative properties. Alcohol can also interfere with the serotonin levels that sertraline is trying to balance.
What you should do
Back to contentsIt is best to avoid or strictly limit alcohol while taking sertraline. If you do choose to drink, keep your intake very low and see how you feel in a safe environment. Do not drive or operate machinery if you have consumed alcohol with your medication.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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