Can I take 50 and Mercaptopurine together?

Why this happens

Mercaptopurine is broken down in the body by an enzyme called TPMT. 5-ASA medicines (like mesalazine) can block this enzyme. When the enzyme is blocked, the levels of mercaptopurine in your blood can rise to dangerous levels, leading to toxic effects on your bone marrow.

You must speak to your doctor before taking these two medicines together. If your doctor decides you need both, they will need to monitor your blood counts very closely and may need to lower your dose of mercaptopurine. Seek medical help immediately if you develop signs of infection, such as a fever, sore throat, or unexplained bruising.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.