git add

Globalseo is still translating this page...
Skip to main content

Can I take 50 and Xarelto together?

Drug interaction guide

Taking 5-HTP with Xarelto (rivaroxaban) may increase your risk of bleeding or bruising. While 5-HTP is primarily used for mood or sleep, it can affect how your blood platelets work, which may add to the blood-thinning effect of Xarelto.

Video picks for Drug interactions

Continue reading below

Why this happens

Xarelto is an anticoagulant that prevents blood clots. 5-HTP increases serotonin levels in the body. Serotonin plays a role in how platelets (the cells that help blood clot) stick together. Combining these two can potentially interfere with the body's ability to stop bleeding.

Use caution if combining these two. You should speak with your doctor or pharmacist before starting 5-HTP while taking Xarelto. Watch closely for signs of unusual bleeding, such as bleeding gums, nosebleeds, dark or tarry stools, or large unexplained bruises. If you experience any severe bleeding, seek medical help immediately.

Continue reading below

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Continue reading below

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.