Skip to main content

Can I take 60 and Alcohol together?

Drug interaction guide

Combining duloxetine (Cymbalta) with alcohol can increase the risk of liver damage and may worsen the side effects of the medication, such as dizziness, sleepiness, and difficulty concentrating. It can also make the symptoms of depression or anxiety worse.

Continue reading below

Why this happens

Both duloxetine and alcohol are processed by the liver; using them together puts extra strain on this organ. Additionally, both substances affect the central nervous system, leading to an 'additive' effect where the sedative properties of both are amplified.

It is best to avoid or strictly limit alcohol while taking duloxetine. You should never drink heavily while on this medication. If you choose to have a drink, do so only occasionally and in very small amounts, but be aware that you may feel the effects of alcohol much more quickly. Do not drive or operate machinery if you have consumed any alcohol.

Continue reading below

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.