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Can I take 7.5mg and Mirtazapine together?

Drug interaction guide

Taking zopiclone and mirtazapine together can make you feel extremely sleepy, dizzy, and confused. It significantly increases the risk of falls, especially in older people, and can cause severe breathing difficulties or a very deep sleep from which it is hard to wake up.

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Why this happens

Both medicines work by slowing down the central nervous system (the brain and nerves). When used at the same time, their sedative effects add together, making the overall effect much stronger than if they were taken alone.

You should only take these two medicines together if your doctor has specifically told you to do so. If you are prescribed both, take them exactly as directed, usually right before bed. Do not drive, operate machinery, or perform any tasks that require alertness. It is illegal to drive if your ability is impaired by these medicines. It is best to avoid or strictly limit alcohol, as it will make these dangerous side effects much worse.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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