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Can I take 7.5mg and Oxynorm together?

Drug interaction guide

Taking Zopiclone and OxyNorm (oxycodone) together can cause extreme sleepiness, severe breathing difficulties, and a state of unconsciousness (coma). In some cases, this combination can be fatal because both drugs tell your brain to slow down your breathing.

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Why this happens

Both medicines are 'central nervous system depressants'. This means they both slow down brain activity. When used together, their effects add up, significantly increasing the risk of sedation and suppressed breathing.

You should only take these two medicines together if they have been specifically prescribed by the same doctor who is aware you are taking both. Do not drive or operate machinery. If you feel unusually sleepy, dizzy, or find it difficult to breathe, seek emergency medical help immediately. It is best to avoid or strictly limit alcohol, as it will make these dangerous side effects much worse.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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