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Can I take 90 and Duloxetine together?

Drug interaction guide

Taking duloxetine and alcohol together can increase the risk of serious liver damage. It can also make the side effects of duloxetine worse, such as feeling very sleepy, dizzy, or having trouble concentrating. Alcohol can also make the symptoms of depression or anxiety worse, which is what duloxetine is often used to treat.

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Why this happens

Both duloxetine and alcohol are processed by the liver. Combining them puts extra strain on the liver, which can lead to injury. Additionally, both substances affect the central nervous system; when taken together, they have an 'additive' effect, meaning they significantly increase drowsiness and impair your coordination and judgement.

It is best to avoid or strictly limit alcohol while taking duloxetine. You should never drink heavily or engage in 'binge drinking' while on this medication. If you choose to have a drink, keep it to a very small amount and see how you feel, but be aware that your tolerance will be much lower. If you have a history of liver problems or heavy alcohol use, you must speak to your doctor before taking these together.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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