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Can I take 90 and Sumatriptan together?

Drug interaction guide

Taking these two medicines together can lead to a rare but very serious condition called serotonin syndrome. This happens when there is too much of a chemical called serotonin in your brain and body. Symptoms can include feeling very agitated, confused, sweating, shivering, a fast heartbeat, muscle twitching, or diarrhoea. In severe cases, it can lead to seizures or loss of consciousness.

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Why this happens

Both St John's Wort and sumatriptan increase the levels or activity of serotonin in the brain. St John's Wort prevents serotonin from being reabsorbed, while sumatriptan mimics serotonin to stop a migraine. When used together, the effect is 'additive', meaning the serotonin levels can rise to a dangerous level.

You should not take St John's Wort if you are using sumatriptan. If you are already taking both, speak to your doctor or pharmacist before stopping, as they can advise you on how to do so safely. If you experience any symptoms of serotonin syndrome, such as confusion, sweating, or a racing heart, seek medical help immediately.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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