Can I take Abilify and Lamictal together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking Abilify (aripiprazole) and Lamictal (lamotrigine) together can increase the risk of certain side effects. You may feel more drowsy, dizzy, or have difficulty concentrating. In some cases, it can affect your physical coordination or lead to a rare but serious skin rash.
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Why this happens
Both medicines affect the central nervous system. When used together, their sedative effects can add up (pharmacodynamic interaction). While they do not significantly change each other's levels in the blood, their combined impact on brain chemistry increases the likelihood of side effects.
What you should do
Back to contentsYou should use caution when starting this combination. Do not drive or operate machinery until you are certain the medicines do not make you too drowsy or dizzy. It is illegal to drive if your driving is impaired by these medicines. Contact your doctor immediately if you develop a skin rash, fever, or swollen glands. Always follow your doctor's specific dosing instructions.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Can I take Abilify and Fluoxetine together?
Taking fluoxetine with Abilify (aripiprazole) can significantly increase the amount of Abilify in your bloodstream. This makes you much more likely to experience side effects such as extreme sleepiness, restlessness (feeling like you cannot sit still), uncontrollable body movements (tremors or twitching), and dizziness. There is also a small but serious risk of a heart rhythm problem called QT prolongation.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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