Can I take Abilify and Ondansetron together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together can increase the risk of a serious heart rhythm problem. Both drugs can affect the electrical signal that tells your heart when to beat. If this signal is disrupted, it can lead to a fast or irregular heartbeat, which may cause dizziness, fainting, or in rare cases, more serious heart complications.
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Why this happens
Both aripiprazole (Abilify) and ondansetron can cause 'QT prolongation'. This means they both slow down the electrical recharging of the heart muscle after each beat. When used together, this effect can be added together (additive effect), increasing the risk of an abnormal heart rhythm.
What you should do
Back to contentsYou should speak to your doctor before taking these two medicines together. Your doctor may want to perform a simple heart trace (ECG) to check your heart's electrical activity or monitor your mineral levels (like magnesium and potassium) through a blood test. Seek medical help immediately if you feel your heart racing, feel very dizzy, or faint while taking these medications.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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