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Can I take Abiraterone and Eligard together?

Drug interaction guide

Both abiraterone and Eligard (leuprorelin) can cause a specific change in the heart's electrical rhythm called 'QT prolongation'. When taken together, this effect can be stronger, potentially leading to a serious irregular heartbeat. Additionally, both medications can cause similar side effects such as hot flushes, bone thinning (osteoporosis), and high blood sugar.

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Why this happens

This is a 'pharmacodynamic' interaction. Both drugs independently have the potential to delay the heart's electrical recharging phase (prolong the QT interval). Combining them increases the risk of this electrical disturbance. They also have overlapping side effect profiles because they both work by significantly lowering testosterone levels.

You should use these medications together only under the close supervision of your specialist. Your doctor may want to perform an ECG (heart trace) to check your heart rhythm and monitor your blood minerals (electrolytes) regularly. Seek immediate medical help if you feel dizzy, faint, or notice a fluttering or pounding heartbeat.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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