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Can I take Acard and Eliquis together?

Drug interaction guide

Taking Acard (aspirin) and Eliquis (apixaban) together significantly increases your risk of serious bleeding. This includes internal bleeding, such as in the stomach or brain, which can be life-threatening. You may also notice that you bruise more easily or that small cuts take much longer to stop bleeding.

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Why this happens

Both medicines are 'blood thinners', but they work in different ways. Acard stops platelets (blood cells) from sticking together, while Eliquis interferes with the proteins that help blood clot. When used together, their effects add up, making it much harder for your blood to clot when it needs to.

Do not take these two medicines together unless a specialist doctor has specifically told you to do so. If a doctor has prescribed both, it is usually for a very specific reason and for a short period. If you are taking Acard over-the-counter, stop and speak to your doctor before taking it with Eliquis. Seek immediate medical help if you notice signs of serious bleeding, such as blood in your urine, black tarry stools, coughing up blood, or a severe headache that won't go away.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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