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Can I take Acard and Milurit together?

Drug interaction guide

Taking Acard (aspirin) and Milurit (allopurinol) together can make Milurit less effective at lowering uric acid levels. It may also slightly increase the risk of an allergic reaction to Milurit.

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Why this happens

Acard (aspirin) can interfere with the way the kidneys remove uric acid from the body, which works against the purpose of Milurit. Additionally, aspirin can sometimes change how the body processes Milurit, potentially increasing the risk of side effects like skin rashes.

You should speak to your doctor before taking these together. If you are taking low-dose Acard (75mg to 150mg) for heart protection, your doctor may tell you to continue, but they will need to monitor your uric acid levels closely. Avoid taking higher doses of aspirin (for pain or fever) while on Milurit, as this significantly reduces the effectiveness of your gout treatment. Seek medical help immediately if you develop a skin rash.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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