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Can I take Adderall and Celecoxib together?

Drug interaction guide

Taking Adderall and celecoxib together may increase the risk of high blood pressure and heart-related issues. Additionally, celecoxib might slightly increase the levels of Adderall in your bloodstream, potentially leading to more side effects like jitteriness, insomnia, or a racing heart.

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Why this happens

Adderall (amphetamine salts) naturally increases blood pressure and heart rate. Celecoxib (an NSAID) can cause the body to retain fluid and affect kidney function, which also raises blood pressure, leading to an additive effect. Furthermore, celecoxib may mildly interfere with the enzymes (CYP2D6) that break down Adderall, causing it to stay in your system longer.

Use this combination with caution. If you have a history of high blood pressure or heart problems, speak to your doctor before taking them together. Monitor your blood pressure regularly and report any symptoms like chest pain, severe headaches, or palpitations to your healthcare provider.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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