Can I take Alcohol and Amitriptyline together?

Why this happens

Both alcohol and amitriptyline are 'central nervous system depressants'. This means they both slow down the activity of your brain and nerves. When taken together, their effects add up (a synergistic effect), making the sedation much stronger than if you had taken either one alone.

It is best to avoid drinking alcohol altogether while taking amitriptyline, especially when you first start the medication or if your dose has just been increased. If you do choose to drink, keep it to a very small amount, stay at home, and do not drive or operate machinery. Speak to your doctor or pharmacist about how to safely manage alcohol while on this treatment.

Mental health conditions

Amitriptyline can increase the risk of suicidal thoughts and self-harm, particularly when you first start taking it or when your dose is changed. Monitor your mood closely and seek urgent medical help if you experience any distressing thoughts.

Heart conditions (e.g. recent heart attack, heart rhythm disorders)

You must not take amitriptyline if you have recently had a heart attack or have certain heart rhythm problems, as it can affect the electrical signals in your heart and increase the risk of a fatal arrhythmia.

Glaucoma

Amitriptyline can increase the pressure inside your eye. Do not take this medicine if you have acute glaucoma, as it may significantly worsen the condition.

Caffeine (Coffee, Tea, Energy Drinks)

Amitriptyline can sometimes cause a fast or irregular heartbeat. High amounts of caffeine can worsen this effect or increase feelings of anxiety and restlessness, which may counteract the calming effect of the medication.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.