Can I take Alogliptin and Rybelsus together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking alogliptin and Rybelsus (semaglutide) together can significantly increase the risk of your blood sugar dropping too low (hypoglycaemia). Additionally, both medicines work in a similar way on the same hormonal pathway, and using them together is generally not recommended because it does not provide extra benefit but increases the risk of side effects.
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Why this happens
Both drugs target the 'incretin' system. Alogliptin (a DPP-4 inhibitor) prevents the breakdown of natural hormones that lower blood sugar, while Rybelsus (a GLP-1 receptor agonist) mimics those same hormones. Using both is like 'doubling up' on the same biological process, which can lead to an over-correction of blood sugar levels.
What you should do
You should speak to your doctor or pharmacist before taking these together. Clinical guidelines usually recommend stopping the DPP-4 inhibitor (alogliptin) when starting a GLP-1 medicine like Rybelsus. If your doctor has specifically told you to take both, be very alert for signs of low blood sugar, such as feeling shaky, sweaty, dizzy, or hungry.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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