Can I take Am and Hour transdermal together?
Drug interaction guide
Originally published 14 Mar 2026
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There is no known interaction between HRT (Hormone Replacement Therapy) patches and amlodipine. However, it is important to monitor your blood pressure regularly.
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Why this happens
HRT (oestrogen) can sometimes cause the body to retain salt and water, which may slightly increase blood pressure. Amlodipine is a medicine used to lower blood pressure. While they do not interfere with each other's metabolism, their effects on blood pressure work in opposite directions.
What you should do
Back to contentsYou can safely take these together. Ensure you have your blood pressure checked regularly by your GP or pharmacist to make sure your hypertension remains well-controlled while using HRT.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking ramipril and sertraline together can occasionally cause the level of sodium in your blood to drop too low (a condition called hyponatraemia). This can make you feel tired, confused, or dizzy, and in rare cases, it can be serious. Additionally, both medicines can slightly increase the risk of bleeding, particularly in the stomach.

Treatment and medication
Can I take Levothyroxine and Sertraline together?
Taking sertraline may make your levothyroxine less effective. This could lead to symptoms of an underactive thyroid, such as feeling very tired, feeling cold, or gaining weight. Conversely, if you are already stable on both and stop taking sertraline, your thyroid levels could become too high.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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