Can I take Amitriptyline and Cbd oil together?

Why this happens

CBD can slow down the liver enzymes (specifically CYP2C19 and CYP3A4) that your body uses to break down amitriptyline. This causes the medicine to stay in your system longer. Additionally, both substances have a 'sedating' effect on the brain, meaning they can double up on making you feel sleepy or uncoordinated.

You should speak to your GP or pharmacist before using CBD oil with amitriptyline. If you decide to use them together, start with a very low dose of CBD and monitor yourself closely for increased side effects. Seek medical advice if you feel unusually drowsy, confused, or notice a fast or irregular heartbeat.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.