Can I take Amitriptyline and Docusate together?

Why this happens

Amitriptyline has 'anticholinergic' effects, which means it slows down the movement of the digestive system, leading to hard stools. Docusate works by allowing water and fats to enter the stool, making it softer and easier to pass. They work in opposite ways on the bowel but do not interfere with how the other is absorbed or processed by the body.

It is safe to take these medicines together. If you are taking amitriptyline and find you are frequently constipated, ensure you also drink plenty of water and eat high-fibre foods. Speak to your pharmacist or doctor if the constipation does not improve with docusate.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.