Can I take Amitriptyline and Evening primrose oil together?

Why this happens

Amitriptyline is known to lower the 'seizure threshold', meaning it makes it slightly easier for a seizure to occur. Evening primrose oil contains chemicals that may also lower this threshold. When used together, these effects can add up, making a seizure more likely.

You should speak to your doctor or pharmacist before taking evening primrose oil if you are prescribed amitriptyline. If you have a history of epilepsy or seizures, it is generally recommended to avoid evening primrose oil while taking this medication. If you decide to take both and experience any unusual jerking movements, confusion, or loss of consciousness, seek medical help immediately.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.