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Can I take Amlodipine and Hydralazine together?

Drug interaction guide

Taking amlodipine and hydralazine together can cause your blood pressure to drop lower than intended. This may make you feel dizzy, lightheaded, or faint, especially when you stand up quickly. You might also notice an increased heart rate or swelling in your ankles.

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Why this happens

Both medicines work by relaxing and widening your blood vessels to lower blood pressure, but they do so in different ways. When used together, their effects add up (an additive effect), which can lead to a much stronger drop in blood pressure than taking either one alone.

This combination is often prescribed by specialists for difficult-to-treat high blood pressure, but it requires careful monitoring. You should monitor your blood pressure regularly at home. To avoid dizziness, get up slowly from a sitting or lying position. If you feel very dizzy, faint, or notice a rapid heartbeat, contact your doctor. Do not stop taking either medication without medical advice.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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