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Can I take Apixaban and Multivitamins together?

Drug interaction guide

Most standard multivitamins are safe to take with apixaban. However, some multivitamins contain high doses of Vitamin K, which can slightly interfere with how blood thinners work, or Vitamin E and herbal extracts (like Ginkgo or Garlic) which can increase the risk of bleeding.

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Why this happens

Apixaban works by blocking a specific clotting factor. While Vitamin K does not directly block apixaban (unlike warfarin), very high doses can affect the body's overall clotting balance. Conversely, high doses of Vitamin E or certain herbal components in 'specialised' multivitamins can have their own mild blood-thinning effects, which could add to the effect of apixaban.

Check the label of your multivitamin. If it contains standard amounts of vitamins (100% of the Daily Value or less) and no herbal 'extras', it is generally safe. Avoid 'high-strength' Vitamin E supplements or multivitamins with added herbal ingredients like Ginkgo Biloba, Ginseng, or St John's Wort without consulting your pharmacist first. Always inform your doctor about all supplements you are taking.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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