Can I take Azathioprine and Lansoprazole together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Lansoprazole may slightly reduce the amount of azathioprine that your body absorbs. This could potentially make the azathioprine slightly less effective at controlling your condition.
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Why this happens
Azathioprine needs a certain level of stomach acid to dissolve and be absorbed properly. Lansoprazole works by reducing stomach acid, which can change how well azathioprine enters your bloodstream.
What you should do
Back to contentsIt is generally safe to take these together, but you should monitor your condition closely. If you feel your symptoms are returning or worsening, speak to your doctor. They may suggest taking the two medicines at different times of the day.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking these two medicines together can cause your blood pressure to drop too low and may make you feel very sleepy or dizzy. It can also increase the risk of a rare but serious condition called serotonin syndrome, which affects your nervous system.
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Can I take Levothyroxine and Sertraline together?
Taking sertraline may make your levothyroxine less effective. This could lead to symptoms of an underactive thyroid, such as feeling very tired, feeling cold, or gaining weight. Conversely, if you are already stable on both and stop taking sertraline, your thyroid levels could become too high.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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