Can I take Boots one-a-day hayfever allergy relief and Sertraline together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together can make you feel very sleepy, dizzy, or drowsy. It may also affect your concentration and your ability to perform tasks like driving or using machinery.
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Why this happens
Both medicines affect the central nervous system. Sertraline is an antidepressant (SSRI) and the active ingredient in Boots One-A-Day Hayfever Relief (loratadine) is an antihistamine. While loratadine is a 'non-drowsy' antihistamine, it can still cause mild sedation in some people, which is increased when combined with the effects of sertraline.
What you should do
Back to contentsIt is generally safe to take these together, but you should be cautious. See how the combination affects you before driving or operating machinery. If you feel excessively sleepy or dizzy, speak to your pharmacist about switching to a different hayfever treatment or adjusting the timing of your doses.
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Important precautions
Back to contentsSerotonin Syndrome
Do not take sertraline with other medicines that increase serotonin (such as St John’s Wort or certain strong painkillers like tramadol) as this can cause a life-threatening reaction.
Increased bleeding risk
Sertraline increases your risk of internal bleeding, especially if you also take aspirin, ibuprofen, or blood-thinning medications like warfarin.
Drowsiness and alcohol interaction
While loratadine is generally non-drowsy, combining it with sertraline or alcohol can increase the risk of sleepiness, which may affect your ability to drive or use machinery safely.
Food and drink warnings
Back to contentsAlcohol
It is recommended to avoid drinking alcohol while taking sertraline. Alcohol can increase the sedative effects of the medication, making you feel more drowsy or dizzy, and may worsen the symptoms of your condition.
Grapefruit juice
Avoid drinking large amounts of grapefruit juice. Grapefruit contains compounds that can increase the levels of sertraline in your blood, which may increase the risk of side effects.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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