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Can I take Butec and Pregabalin together?

Drug interaction guide

Taking Butec (buprenorphine) and pregabalin together can significantly increase the risk of severe drowsiness, dizziness, and breathing difficulties. In some cases, this combination can lead to a dangerous slowing of breathing (respiratory depression) or loss of consciousness.

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Why this happens

Both medications act as central nervous system (CNS) depressants. Butec is an opioid, and pregabalin is a gabapentinoid. When used together, their sedative effects are 'additive', meaning they reinforce each other, making the overall effect on the brain and lungs much stronger than if taken alone.

You must speak to your doctor before taking these together. If your doctor has prescribed both, they will likely start you on the lowest possible doses and monitor you closely. Seek immediate medical help if you experience extreme sleepiness, shallow or slow breathing, or if you feel like you might faint. Avoid driving or operating machinery until you know how this combination affects you.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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