Can I take Clopidogrel and Paracetamol together?

Why this happens

Clopidogrel works by preventing platelets from sticking together to form clots. Paracetamol works on pain signals in the central nervous system and does not affect platelet function or the lining of the stomach, meaning it does not increase the risk of bleeding.

You can safely take paracetamol at the recommended dose while taking clopidogrel. However, you should avoid anti-inflammatory painkillers like ibuprofen or aspirin (unless specifically prescribed by your doctor), as these can significantly increase your risk of bleeding when combined with clopidogrel.

Surgery or dental work

You must tell any surgeon, anaesthetist, or dentist that you are taking clopidogrel. You may need to stop taking it 7 days before any planned procedure to prevent excessive bleeding.

Stomach ulcers or bleeding disorders

Do not take clopidogrel if you have an active stomach ulcer or any condition causing active bleeding. Seek urgent medical help if you notice signs of internal bleeding, such as black, tarry stools or vomiting blood.

Severe liver disease

If you have severe liver problems, you must not take paracetamol without medical supervision, as even standard doses can cause further liver damage.

Alcohol

Drinking alcohol while taking clopidogrel can increase the risk of bleeding in your stomach and intestines. It is best to limit your alcohol intake. You should avoid drinking large amounts of alcohol while taking paracetamol. Chronic heavy drinking increases the risk of serious liver damage if you take more than the recommended dose of paracetamol.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.