Can I take Esomeprazole and Trazodone together?
Drug interaction guide
Originally published 25 Jan 2026
Répond aux besoins du patient lignes directrices éditoriales
- TéléchargerTélécharger
- Partager
- Langue
- Discussion
Esomeprazole may reduce the amount of trazodone that your body absorbs. This could potentially make trazodone less effective at treating your symptoms (such as depression or sleep issues). Additionally, both medications can rarely affect the electrical activity of your heart, though this risk is generally low.
Dans cet article :
Poursuivre la lecture ci-dessous
Why this happens
Esomeprazole reduces stomach acid. Trazodone needs an acidic environment to dissolve properly so it can be absorbed into the bloodstream. Lower acid levels mean less medicine gets into your system. There is also a theoretical risk of 'QT prolongation' (a change in heart rhythm) when these types of drugs are used together.
What you should do
You can generally take these together, but monitor your mood or sleep patterns closely. If you feel your trazodone is not working as well as it used to, or if you experience any unusual heart palpitations or dizziness, speak with your doctor. They may need to adjust your dose or the timing of when you take your tablets.
Poursuivre la lecture ci-dessous
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Traitement et médicaments
Can I take Evana heavy period relief and Mefenamic acid together?
Taking these two medicines together significantly increases your risk of serious stomach problems, such as stomach ulcers, bleeding, or irritation of the stomach lining. It can also put extra strain on your kidneys.
Traitement et médicaments
Can I take Citalopram and Co codamol together?
Taking these two medicines together can increase the risk of a rare but serious condition called serotonin syndrome. It can also make you feel more drowsy or dizzy than usual. Additionally, citalopram may slightly reduce how well the codeine part of the co-codamol works to relieve your pain.
Poursuivre la lecture ci-dessous
Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets liés à la santé.
Vous ne vous sentez pas bien ?
Évaluez gratuitement vos symptômes en ligne
Inscrivez-vous à la newsletter destinée aux patients
Votre dose hebdomadaire de conseils santé clairs et fiables, rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.