Puis-je prendre Fluoxetine et Venlafaxine ensemble ?

You should not take fluoxétine et venlafaxine together unless specifically instructed and closely monitored by a specialist.

Both fluoxetine and venlafaxine work by increasing serotonin levels in the brain. When used together, their effects add up (an additive effect).

Additionally, fluoxetine can slow down the way your liver breaks down venlafaxine, causing the levels of venlafaxine in your blood to rise even higher.

Comment savoir si vous avez une interaction médicamenteuse

You may be experiencing a drug interaction between fluoxetine and venlafaxine if you notice:

• Agitation, agitation ou confusion.

• Shivering, sweating or fever.

• Muscle twitching or stiffness.

• Battement de cœur rapide.

• Diarrhée.

• Maux de tête.

• Se sentir anormalement anxieux ou hyperactif.

These can be signs of syndrome sérotoninergique, a rare but serious reaction.

Consultez immédiatement un médecin si vous avez :

• High fever.

• Severe agitation or confusion.

• Convulsions.

• Battement de cœur irrégulier.

• Perte de connaissance.

Ce que vous devriez faire

If you are experiencing any of the above symptoms you should:

• Seek emergency medical help (call 999 / go to A&E) if symptoms are severe, worsening quickly, or include high fever, confusion, seizures, or loss of consciousness.

• Do not take any further doses until you have spoken to a healthcare professional.

• Do not stop either medicine suddenly unless a doctor tells you to, as this can cause withdrawal symptoms.

If your doctor is switching you from one to the other, they will usually advise a 'washout' period (a gap of a few weeks) because fluoxetine stays in your system for a long time.

Précautions importantes

Suicidal thoughts and worsening of depression

These medicines can increase thoughts of self-harm or suicide, particularly in the first few weeks of treatment or when the dose is changed. Patients under 25 are at higher risk and must be monitored closely by family or carers.

Syndrome sérotoninergique

Taking these with other medicines that affect serotonin (such as St John’s Wort, tramadol, or triptans for migraine) can cause a life-threatening reaction. Seek immediate medical help if you experience high fever, agitation, confusion, or muscle twitching.

Abrupt withdrawal (Discontinuation Syndrome)

Stopping these medicines suddenly can cause severe withdrawal symptoms, including 'brain zaps' (electric shock sensations), intense dizziness, and anxiety. You must taper the dose slowly under medical supervision.

Hypertension artérielle (Hypertension)

La venlafaxine peut augmenter considérablement votre tension artérielle. Votre médecin doit vérifier votre tension artérielle avant le début du traitement et la surveiller régulièrement pendant que vous prenez ce médicament.

Bleeding disorders or use of blood thinners

These medicines can increase your risk of bleeding, especially if you are already taking medicines that thin the blood (like warfarin) or non-steroidal anti-inflammatory drugs (like ibuprofen).

Diabète

Fluoxetine can affect your blood sugar levels. You may need to monitor your blood glucose more closely as your dose of insulin or antidiabetic medicine might need adjusting.

Avertissements sur la nourriture et les boissons

Alcool

It is best to avoid or strictly limit alcohol while taking these medicines. Combining alcohol with antidepressants can increase drowsiness, dizziness, and coordination problems. It can also make your depression or anxiety symptoms worse.

Caféine (Café, thé, boissons énergisantes)

Fluoxetine and venlafaxine can sometimes cause jitteriness, anxiety, or difficulty sleeping. High amounts of caffeine can make these side effects worse. Monitor how you feel and consider reducing caffeine intake if you feel overly restless.

Utilisation d'autres médicaments

Prendre plusieurs médicaments ? Notre Vérificateur d'Interactions Médicamenteuses vous aide à vérifier si vos ordonnances, médicaments en vente libre et suppléments peuvent être pris ensemble en toute sécurité. Recherchez simplement vos médicaments pour voir les interactions potentielles et ce qu'il faut faire à leur sujet.

Avertissement

Ces informations sont fournies à des fins éducatives générales uniquement et ne doivent pas être considérées comme un substitut aux conseils médicaux professionnels. Consultez toujours votre médecin généraliste, votre pharmacien ou un autre professionnel de santé qualifié avant de prendre des décisions concernant vos médicaments. Les circonstances individuelles peuvent varier, et seul un professionnel de santé connaissant votre historique médical peut fournir des conseils personnalisés.