Can I take Ibuprofen and Side effects together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Ibuprofen is a medication used to treat pain and inflammation, but it can cause its own side effects. When we talk about 'interactions' with side effects, we usually mean that ibuprofen can make existing health problems worse or increase the risk of certain symptoms occurring. Common side effects include stomach irritation, indigestion, and, in some cases, reduced kidney function or increased blood pressure.
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Why this happens
Ibuprofen works by blocking enzymes called COX-1 and COX-2. While this reduces pain, it also reduces the protective lining of the stomach and affects blood flow to the kidneys. This is why it can cause stomach ulcers or fluid retention.
What you should do
Back to contentsAlways take ibuprofen with food or a glass of milk to protect your stomach. Do not take more than the recommended dose. If you have a history of stomach ulcers, asthma, high blood pressure, or kidney problems, speak to your doctor or pharmacist before using it. If you notice black, tarry stools or severe stomach pain, stop taking it immediately and seek medical help.
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Important precautions
Back to contentsAsthma
Do not take this medicine if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.
Stomach ulcers or bleeding
Avoid this medicine if you have ever had a stomach ulcer, perforation, or bleeding. It can cause serious damage to the stomach lining, even after a few doses.
Pregnancy (third trimester)
Do not take ibuprofen if you are more than 20 weeks pregnant. It can cause serious heart and kidney problems in the unborn baby and reduce amniotic fluid levels.
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking ibuprofen can increase the risk of stomach irritation and bleeding. It is best to limit or avoid alcohol, especially if you are taking ibuprofen long-term or at high doses.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Can I take Amlodipine and Omemprazole together?
There is no significant interaction between amlodipine and omeprazole. It is generally safe to take these two medicines together.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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