Can I take Naproxen and Uribel together?

Why this happens

Naproxen is an NSAID that can irritate the stomach lining and affect kidney function. Uribel contains phenyl salicylate; because both drugs inhibit prostaglandins (chemicals that protect the stomach and support kidney blood flow), their effects can add together, increasing the risk of side effects like stomach pain or reduced kidney clearance.

Use this combination with caution. If you have a history of stomach ulcers, kidney problems, or asthma, speak to your doctor before taking them together. Take these medications with food to protect your stomach. If you notice any unusual bruising, black tarry stools, or persistent stomach pain, stop taking them and contact your doctor immediately.

Asthma or Aspirin Sensitivity

Uribel contains a salicylate. Do not take it if you are allergic to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can cause a severe allergic reaction.

Do not take naproxen if you have asthma that is sensitive to aspirin or other NSAIDs, as it can trigger a life-threatening asthma attack or severe breathing difficulties.

Stomach Ulcers or Bleeding

Naproxen significantly increases the risk of stomach ulcers and internal bleeding. Seek immediate medical help if you experience black, tarry stools or vomit blood.

Both medicines contain ingredients (naproxen and salicylate) that affect blood clotting. Taking them together or with other blood thinners increases your risk of serious bleeding.

Glaucoma or Urinary Retention

Uribel can dangerously increase eye pressure in people with glaucoma and worsen symptoms of an enlarged prostate or bladder obstruction.

Kidney disease / Renal impairment

Do not take Uribel if you have severe kidney disease. It can lead to a dangerous buildup of the ingredients in your blood and may not work effectively to treat your symptoms.

Serotonin Syndrome

Uribel contains methylene blue, which can cause a life-threatening buildup of serotonin (serotonin syndrome) if taken with antidepressants (SSRIs, SNRIs, or MAOIs). Seek immediate medical help if you experience confusion, rapid heartbeat, or muscle stiffness.

Alcohol

It is best to avoid or strictly limit alcohol while taking Uribel. Alcohol can increase the risk of dizziness and drowsiness caused by the hyoscyamine in this medicine. Additionally, alcohol can irritate the bladder, potentially worsening the symptoms you are being treated for. Combining alcohol with medicines containing salicylate or paracetamol increases the risk of liver damage and stomach irritation.

Drinking alcohol while taking naproxen can increase the risk of stomach irritation, stomach ulcers, and internal bleeding. It is best to limit or avoid alcohol.

Food (General)

Naproxen should ideally be taken with or just after food or a glass of milk. This helps to protect your stomach lining and reduce the risk of indigestion or stomach pain.

Cranberry juice and Vitamin C

Uribel requires acidic urine to work effectively. While cranberry juice or Vitamin C supplements are often used for urinary health, you should consult your doctor before using them with Uribel, as they may affect how the medication works.

Alkalising foods and drinks (e.g., milk, citrus fruits, antacids)

Avoid consuming large amounts of foods or drinks that make your urine less acidic (alkaline), such as milk, dairy products, and most citrus fruits. These can prevent the methenamine in Uribel from converting into its active form, making the medicine less effective.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.