Can I take Nefopam and Sertraline together?

Why this happens

Both nefopam and sertraline increase the levels of serotonin in the brain. Sertraline is an SSRI (Selective Serotonin Reuptake Inhibitor) designed for this purpose, but nefopam also has similar effects on serotonin. When used together, the combined effect can push serotonin levels into a range that is toxic to the body.

You should speak to your doctor before taking these two medicines together. While they are sometimes prescribed together, it must be done with caution. If you are already taking both and feel unwell, particularly if you feel confused, agitated, or have muscle twitches, seek medical advice immediately.

Serotonin Syndrome

Taking these medicines together increases the risk of serotonin syndrome, a potentially life-threatening condition. Seek urgent medical help if you experience high fever, agitation, confusion, or muscle twitching.

Epilepsy or Seizures

Nefopam must not be taken if you have a history of epilepsy or seizures, as it can trigger or worsen fits.

Glaucoma or Urinary Retention

Do not take nefopam if you have closed-angle glaucoma or problems passing urine (such as an enlarged prostate), as it can severely worsen these conditions.

Alcohol

You should avoid or strictly limit alcohol while taking these medicines. Both nefopam and sertraline can cause drowsiness and dizziness; alcohol will significantly increase these effects, making you feel more sleepy and increasing the risk of falls or accidents.

Caffeine (Coffee, tea, energy drinks)

Sertraline can sometimes make you feel jittery or anxious, especially when you first start taking it. High amounts of caffeine can worsen these side effects. Monitor how you feel and consider reducing your caffeine intake if you feel restless.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.