Can I take Venlafaxine and Vitamin B12 together?

Why this happens

Venlafaxine is an antidepressant (an SNRI) that works on brain chemicals, while vitamin B12 is a water-soluble vitamin used by the body for nerve health and red blood cell production. They are processed by the body through different pathways and do not interfere with each other's absorption, metabolism, or effectiveness.

You can continue taking both as prescribed. As with any supplement, it is always a good idea to inform your doctor or pharmacist about everything you are taking to ensure your records are up to date.

Depression and anxiety disorders

Venlafaxine can cause an increase in suicidal thoughts or self-harm, particularly when first starting treatment or changing doses. Monitor your mood closely and seek urgent medical help if you notice any distressing changes.

Bleeding disorders

Venlafaxine can increase your risk of bleeding, especially if you are also taking aspirin, NSAIDs (like ibuprofen), or blood-thinning medicines like warfarin. Seek medical advice if you notice unusual bruising or bleeding.

Serotonin Syndrome

Combining venlafaxine with other medicines that affect serotonin (such as St John's Wort or certain painkillers) can cause a life-threatening condition called serotonin syndrome. Symptoms include agitation, hallucinations, fast heartbeat, and muscle stiffness.

Alcohol

It is best to avoid or strictly limit alcohol while taking venlafaxine. Combining alcohol with this medicine can increase drowsiness, dizziness, and the risk of coordination problems. It may also worsen the symptoms of your underlying condition.

It is best to avoid or strictly limit alcohol while taking Vitamin B12. Heavy alcohol consumption can interfere with the body's ability to absorb Vitamin B12 from the gut and can reduce the amount of the vitamin stored in the liver.

Caffeine

Venlafaxine can sometimes increase your blood pressure or heart rate. Consuming high amounts of caffeine (found in coffee, tea, and energy drinks) may worsen these effects or increase feelings of anxiety and restlessness.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.