Chlorambucil tablets
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSLast updated 19 déc. 2022
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Chlorambucil is used to treat a number of different cancers of the blood or lymphatic system.
Respectez vos rendez-vous réguliers avec votre médecin ou votre hôpital. Vous devrez effectuer des analyses de sang fréquentes et des contrôles.
The most common side-effects are feeling sick (nausea), diarrhoea and mouth ulcers.
At a glance
Chlorambucil is a chemotherapy medicine used to treat some cancers.
It works by stopping cancer cells from growing and dividing too quickly.
Take tablets on an empty stomach, one hour before food or three hours after.
Do not break, crush or chew the tablets.
This medicine lowers your protection against infections; tell your doctor if you feel unwell.
Discuss suitable contraception with your doctor, as pregnancy is not advised during treatment.
Store chlorambucil tablets in a refrigerator.
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Video picks for Traitement du cancer et médicaments
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About chlorambucil
Type de médicament | Un médicament de chimiothérapie alkylant |
Utilisé pour | Treatment of cancer |
Disponible sous forme de | Tablet |
Chlorambucil is used to treat some les cancers, particularly cancer of white blood cells and cancers of the lymphatic system. It can be prescribed both for adults and for children.
In cancer, certain cells in the body grow and multiply too fast. Anti-cancer medicines (chemotherapy) like chlorambucil work by preventing the growth and division of cells, and this reduces the number of cancer cells your body makes. Chlorambucil can be used as a treatment on its own, or alongside other medicines to help treat your condition.
Before taking chlorambucil
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you (or, if appropriate, your child) start taking chlorambucil it is important that your doctor or pharmacist knows:
Si vous êtes enceinte ou si vous allaitez.
Si vous avez des problèmes avec le fonctionnement de votre foie.
If you have a kidney problem called nephrotic syndrome.
If you have ever had a fit (seizure) or if you have epilepsy.
Si vous avez une infection ou si vous ne vous sentez pas bien.
Si vous avez un trouble sanguin héréditaire rare appelé porphyrie.
Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.
Si vous avez déjà eu une réaction allergique à un médicament.
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How to take chlorambucil
Retour au sommaireBefore you start this treatment, read any printed information you have been given by your doctor and the leaflet from inside your pack of tablets. The leaflet will give you more information about chlorambucil and a full list of side-effects which you may experience from taking it.
Chlorambucil will be given to you by a specialist doctor who is experienced in treating your condition. Your doctor will calculate what dose is right for you and will tell you how many tablets to take each day - it is important that you take chlorambucil exactly as you have been told. Your dose will also be printed on the label of your pack. If you are unsure about what to do, or if you have any other concerns, you should contact your doctor or hospital clinic for advice.
You should take the tablets when your stomach is empty, which means taking them one hour before eating food, or waiting until three hours afterwards. This is because food prevents chlorambucil from being absorbed by your body, which means the medicine is much less effective for you.
Swallow the tablets with a drink of water. Do not break, crush or chew them.
Try to take chlorambucil at the same time each day, as this will help you to remember to take your doses.
If you are sick shortly after taking a dose, or if you forget a dose, contact your doctor or clinic for advice on what to do. You will be told whether to take the dose again, or to wait until the next dose is due.
Tirer le meilleur parti de votre traitement
Retour au sommaireYou must try to keep your regular appointments with your doctor or hospital. This is so your doctor can check on your progress. You will need to have regular blood tests and check-ups during your treatment.
Chlorambucil lowers the number of white cells in your blood, increasing the chance of you getting an infection. You should take certain precautions to reduce the risk of infection - if possible, avoid people with infections and let your doctor know if you think you are getting a sore throat or if you have a high temperature (fever).
It is important that you do not get pregnant or father a child while you are taking chlorambucil. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner.
If you intend to have children in the future, you should ask your doctor for advice about family planning before you begin taking chlorambucil. There is a risk of reduced fertility after treatment with chlorambucil.
This medicine lowers your natural protection against infections. It is important to protect yourself from serious illness by having any vaccinations your doctor offers you. If you live with other people they can also help protect you by having their vaccinations when invited.
Certains vaccins peuvent ne pas convenir aux personnes ayant un système immunitaire affaibli. Informez toujours la personne qui vous vaccine que vous prenez ce médicament.
Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.
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Can chlorambucil cause problems?
Retour au sommaireAlong with their useful effects, most medicines can cause side-effects although not everyone experiences them. Before you start treatment with chlorambucil, your doctor will discuss with you the possibility of unwanted side-effects occurring. The table below contains some of the most common ones associated with chlorambucil. You will find a full list of side-effects in the manufacturer's information leaflet supplied with your tablets.
Common chlorambucil side-effects - these affect fewer than 1 in 10 people who take this medicine | Que puis-je faire si je ressens cela ? |
Se sentir malade (nausée) ou être malade (vomissements) | Privilégiez des aliments simples. Informez-en votre médecin, car un médicament contre la nausée pourrait être utile |
Diarrhée | Buvez beaucoup d'eau pour remplacer les fluides perdus. Si cela continue, consultez votre médecin |
Ulcères buccaux | Se brosser les dents 2 à 3 fois par jour avec une brosse à dents souple et utiliser régulièrement un bain de bouche peut aider à prévenir cela. Si les aphtes deviennent un problème, consultez votre médecin |
Less common but more serious chlorambucil side-effects | Que puis-je faire si je ressens cela ? |
Unexpected bruising or bleeding, a high temperature (fever), or symptoms of an infection | Informez votre médecin de cela immédiatement |
Éruption cutanée | Let your doctor know about this as soon as possible. Some skin rashes can be a sign of an allergic-type reaction |
Si vous ressentez d'autres symptômes que vous pensez être dus à ce médicament, parlez-en à votre médecin ou à votre pharmacien.
How to store chlorambucil
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Store the tablets in a refrigerator.
Return any unused or unwanted tablets to your pharmacy to destroy. These will need special disposal.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Yellow Card website.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
Can chlorambucil be used for all types of cancer?
No, chlorambucil is specifically used to treat certain types of cancer, particularly those affecting white blood cells and the lymphatic system. It works by preventing the rapid growth and division of cancer cells.
How important is it to take chlorambucil on an empty stomach?
It is very important to take chlorambucil on an empty stomach. This means you should take the tablets one hour before eating food or wait three hours after a meal. Food can prevent the medicine from being absorbed properly by your body, making it much less effective.
What should I do if I forget to take a dose of chlorambucil?
If you forget a dose, you should contact your doctor or clinic for advice. They will tell you whether to take the missed dose or to wait until your next scheduled dose.
Why do I need regular blood tests while taking chlorambucil?
Regular blood tests are necessary so your doctor can monitor your progress and check for any changes, especially as chlorambucil can lower the number of white blood cells in your body, increasing your risk of infection.
Can chlorambucil affect my ability to have children in the future?
Yes, there is a risk of reduced fertility after treatment with chlorambucil. If you intend to have children in the future, you should discuss this with your doctor for advice about family planning before you start treatment.
Are there specific precautions I should take to avoid infections while on this medication?
Yes, chlorambucil can lower your white blood cell count, making you more susceptible to infections. You should try to avoid people who have infections. Also, let your doctor know immediately if you develop symptoms like a sore throat or a high temperature (fever).
What should I do if I experience mouth ulcers while taking chlorambucil?
Mouth ulcers are a common side-effect. Brushing your teeth two to three times a day with a soft toothbrush and regularly using a mouth rinse may help to prevent them. If they become a problem, you should speak with your doctor.
How should I store my chlorambucil tablets?
You should store chlorambucil tablets in a refrigerator and always keep them out of the reach and sight of children. Any unused or unwanted tablets should be returned to your pharmacy for special disposal.
Lectures complémentaires et références
- Manufacturer's PIL, Chlorambucil 2 mg tablets; Aspen Pharma Trading Ltd, The electronic Medicines Compendium. Dated January 2017.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Prochaine révision prévue : 18 juin 2027
19 déc. 2022 | Dernière version

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