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Comprimés de cyclopenthiazide

Clinical author's note Michael Stewart 22/04/2019: Navidrex® and Navispare® tablets have been discontinued in the UK. At the time of review there are no branded or generic products containing cyclopenthiazide available in the UK. Cyclopenthiazide may still be available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing. Please also refer to the manufacturer's information supplied with your medicine.

Cyclopenthiazide is a 'water tablet' (a diuretic).

Il est préférable de le prendre le matin.

Any side-effects are usually mild, but may include feeling sick or dizzy.

At a glance

  • Cyclopenthiazide is a 'water tablet' (diuretic) used to treat high blood pressure, fluid retention, and heart failure.

  • It works by making your kidneys pass out more urine.

  • Take your dose in the morning to avoid disturbing your sleep.

  • Your doctor may monitor your salt levels with blood tests.

  • Tell your doctor if you experience constant thirst or a dry mouth, as this may indicate dehydration.

  • Seek medical advice before drinking alcohol or taking other medicines with cyclopenthiazide.

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About cyclopenthiazide

Type de médicament

A thiazide diuretic

Utilisé pour

High blood pressure; fluid retention; heart failure

Aussi appelé

Navidrex®, Navispare® (discontinued)

Disponible sous forme de

Comprimés

Cyclopenthiazide belongs to a group of medicines called thiazide diuretics. A diuretic is a medicine which increases the amount of urine that you pass out from your kidneys. They are often referred to as 'water tablets'. Diuretics are a common treatment for l'hypertension artérielle (hypertension). They are also used to clear excess fluid from your body in conditions where your body retains more than it needs. This is called œdème. Cyclopenthiazide is also useful in people who have une insuffisance cardiaque. Heart failure is a condition where your heart is not functioning as well as it should.

Diuretics like cyclopenthiazide work by interfering with the transport of salt and water across certain cells in your kidneys. The effect of this is to make your kidneys pass out more urine. The removal of fluid reduces your blood pressure and helps reduce the work your heart has to do.

Cyclopenthiazide is usually given alongside other diuretics to treat high blood pressure. When it is used like this, you may be prescribed a combination tablet, such as Navispare®. This brand contains cyclopenthiazide with amiloride. Combination tablets like this help to reduce the number of tablets you need to take each day.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking cyclopenthiazide it is important that your doctor knows:

  • Si vous êtes enceinte ou si vous allaitez.

  • Si vous avez des problèmes avec le fonctionnement de votre foie, ou des problèmes avec le fonctionnement de vos reins.

  • If you have gout, diabetes or an inflammatory condition called systemic lupus erythematosus (also called lupus, or SLE). These conditions can be made worse by medicines like cyclopenthiazide.

  • Si un médecin vous a informé que vous avez des niveaux faibles de sodium ou de potassium dans votre sang, ou des niveaux élevés de calcium dans votre sang.

  • If you have a problem with your adrenal glands, called Maladie d'Addison.

  • Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.

  • Si vous avez déjà eu une réaction allergique à un médicament.

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  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about cyclopenthiazide and will provide you with a full list of the side-effects which you may experience from taking it.

  • Take cyclopenthiazide tablets exactly as your doctor tells you to. The usual dose is ½-1 tablet daily. Your doctor is likely to recommend that you take your dose in the morning. This is so it works during the day and your sleep is not disturbed by you needing to get up to go to the toilet during the night.

  • Swallow the tablet with a drink of water. You can take it either with or without food.

  • If you forget to take a dose, take it as soon as you remember. However, if it is late afternoon when you remember, leave out the forgotten dose and take your next dose as usual on the following day. Do not take two doses on the same day to make up for a missed dose.

  • 'Water tablets' (diuretics) like cyclopenthiazide help you to lose water. Occasionally you may lose too much and become lacking in fluid in the body (dehydrated). Let your doctor know if you feel constantly thirsty, your mouth is dry, or your skin looks and feels dry.

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. The salt balance in your bloodstream may be upset by cyclopenthiazide and your doctor may want you to have a blood test from time to time to check for this.

  • If you have been prescribed cyclopenthiazide for high blood pressure (hypertension), your treatment is likely to be long-term. Although many people with high blood pressure do not feel unwell, if left untreated, high blood pressure can harm your heart and damage your blood vessels. This damage may later result in a heart attack, stroke, or kidney problems, so it is important that you continue to take the tablets regularly to help reduce the risk of this. You may also be given some lifestyle and dietary advice by your doctor, such as stopping smoking, reducing the amount of salt in your diet, eating more fruit and vegetables and less saturated fat, and taking some regular exercise. Following this advice will also help to reduce the risk of damage to your heart and blood vessels.

  • Ask your doctor for advice before drinking alcohol while you are on cyclopenthiazide. Alcohol will add to the blood pressure-lowering effect of cyclopenthiazide which will increase the possibility of you experiencing side-effects such as dizziness.

  • If you buy any medicines, check with a pharmacist that they are suitable to take alongside cyclopenthiazide.

  • Si vous devez subir une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with cyclopenthiazide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common cyclopenthiazide side-effects

Que puis-je faire si je ressens cela ?

Sensation de malaise (nausée), maux d'estomac

This is usually mild, but it may help to take cyclopenthiazide after food if you are not already doing so

Feeling dizzy, particularly when you stand up (due to low blood pressure)

Getting up more slowly should help. Do not drive and do not use tools or machines while affected

Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.

  • Gardez tous les médicaments hors de la portée et de la vue des enfants.

  • Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.

Informations importantes sur tous les médicaments

Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous immédiatement au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.

Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.

Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.

Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.

Signaler les effets secondaires d'un médicament ou d'un vaccin

Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Yellow Card website.

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Questions fréquemment posées

What is cyclopenthiazide primarily used for?

Cyclopenthiazide is a medicine that helps increase the amount of urine your kidneys pass out. It is commonly used to treat high blood pressure and to clear excess fluid from the body in conditions like oedema or heart failure.

How does cyclopenthiazide work in the body?

This medicine, a 'water tablet', works by affecting how salt and water are transported across cells in your kidneys. This action causes your kidneys to make more urine. This extra fluid removal helps lower your blood pressure and reduces the effort your heart needs to make.

Can I take cyclopenthiazide with other diuretics?

Yes, cyclopenthiazide is often given with other diuretics, especially for high blood pressure. Sometimes, you might be prescribed a combination tablet, which includes cyclopenthiazide and another medicine, to reduce the total number of tablets you need to take each day.

What should I do if I miss a dose of cyclopenthiazide?

If you forget to take a dose, take it as soon as you remember. However, if it's late afternoon when you remember, skip the forgotten dose and take your next dose at the usual time the following day. Never take two doses on the same day to catch up for a missed dose.

What are the common side-effects of cyclopenthiazide and how can I manage them?

Common side-effects include feeling sick (nausea), stomach upset, and dizziness, especially when standing up. For nausea and stomach upset, taking the tablet after food might help. If you feel dizzy, try getting up more slowly. If these issues continue or become bothersome, speak to your doctor or pharmacist.

Why is it important to have regular blood tests while taking cyclopenthiazide?

Cyclopenthiazide can sometimes affect the balance of salts in your bloodstream. Your doctor may ask you to have regular blood tests to check these salt levels and ensure they remain balanced.

Can I drink alcohol while taking cyclopenthiazide?

You should ask your doctor for advice before drinking alcohol. Alcohol can increase the blood pressure-lowering effect of cyclopenthiazide, which could make you more likely to experience side-effects like dizziness.

Lectures complémentaires et références

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About the authorView full bio

Author image

Michael Stewart, MRPharmS

Medicine Leaflet Review Manager – Contractor, Pharmacist

BPharm (Hons), MRPharmS

Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.

About the reviewer

Author image

Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

Historique de l'article

Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.

  • Prochaine révision prévue : 31 mars 2028
  • 31 mars 2025 | Dernière version

    Dernière mise à jour par

    Michael Stewart, MRPharmS

    Revu par

    Sid Dajani
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