Hydralazine pour l'hypertension artérielle
Apresoline
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 12 déc. 2022
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Hydralazine is used to control high blood pressure (hypertension).
Treatment with hydralazine is usually long-term.
The most common side-effects are headaches and being aware of your heartbeat.
En un coup d'œil
Hydralazine is a medicine used to treat high blood pressure, often with other medicines.
It works by relaxing blood vessel walls, which lowers blood pressure.
It is usually taken twice a day, with or without food.
Common side-effects include headache and a fast heartbeat.
Tell your doctor if you have other conditions, especially heart or liver problems.
Do not stop taking hydralazine without speaking to your doctor.
About hydralazine
Type de médicament | A vasodilator antihypertensive medicine |
Utilisé pour | The treatment of high blood pressure |
Aussi appelé | Apresoline® |
Disponible sous forme de | Comprimés |
Although many people with hypertension artérielle (hypertension) do not feel unwell, it is still important that high blood pressure be treated. If left untreated, high blood pressure is a risk factor that can increase your chance of developing heart disease, a stroke, and other serious conditions. Hydralazine will be prescribed alongside other medicines to control high blood pressure.
Hydralazine works by relaxing the muscles in the walls of your blood vessels. This means that your blood vessels widen, which reduces your blood pressure and allows blood and oxygen to circulate more freely around your body. Hydralazine will only be prescribed for you if other treatments are not suitable or effective, as it can increase the amount of water and salt in your body and can increase your heart rate. The other medicines you are prescribed to take alongside it will help to control these side-effects.
Hydralazine is occasionally prescribed by hospital doctors for other heart conditions. If you have been prescribed it for a reason other than high blood pressure, speak with your doctor if you have any questions about your treatment.
Before taking hydralazine
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking hydralazine it is important that your doctor knows:
If you have a condition called systemic lupus erythematosus. This is an inflammatory condition also called lupus, or SLE.
Si vous avez des problèmes avec le fonctionnement de votre foie, ou si vous avez des problèmes avec le fonctionnement de vos reins.
If you have a problem with your blood vessels, such as coronary artery disease or cerebrovascular disease.
if you have a heart condition or have recently had a heart attack.
Si vous êtes enceinte ou si vous allaitez.
Si vous avez un trouble sanguin héréditaire rare appelé porphyrie.
Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.
Si vous avez déjà eu une réaction allergique à un médicament.
How to take hydralazine
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about hydralazine and will provide you with a full list of the side-effects which you could experience from taking the tablets.
Take hydralazine exactly as your doctor tells you to. It is usual to take one tablet twice a day. Try to take your doses at similar times of day each day, as this will help you to remember to take them regularly. There are two strengths of hydralazine tablet - it is usual to take the 25 mg strength tablet to begin with, but this may later be increased to the higher 50 mg strength tablet. Increasing your dose gradually allows your doctor to make sure that you have the dose that best helps your condition, but also keeps unwanted side-effects to a minimum.
Swallow the tablet whole with a drink of water. You can take hydralazine either with or without food.
If you forget to take a dose at your usual time, take it as soon as you remember unless your next dose is due. If your next dose is due then take the dose which is due but leave out the forgotten one. Do not take two doses together to make up for a missed dose.
Tirer le meilleur parti de votre traitement
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. You will need to have regular blood pressure measurements, and also some blood and urine tests from time to time.
Your doctor will advise you on what lifestyle changes you can make to help your condition. These could include losing weight if you are overweight, taking regular physical activity, eating a healthy diet, cutting back on the amount of alcohol you drink, stopping smoking, and reducing the amount of salt in your meals and caffeine in your drinks. It is important that you follow any advice you are given.
If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because some medicines (particularly some anti-inflammatory painkillers) can interfere with the way hydralazine works.
Treatment with hydralazine is usually long-term unless you experience an adverse effect. Continue to take the tablets unless you are advised otherwise by your doctor.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking hydralazine. This is because some anaesthetics can affect your blood pressure.
Can hydralazine cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with hydralazine. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common hydralazine side-effects (ces effets touchent plus de 1 personne sur 10) | Que puis-je faire si je ressens cela ? |
Maux de tête | Buvez beaucoup d'eau et demandez à votre pharmacien de vous recommander un analgésique approprié. Si les maux de tête persistent, consultez votre médecin |
A fast heartbeat, the sensation of having a 'thumping heart' (palpitations) | Si vous avez des inquiétudes, consultez votre médecin |
Commun hydralazine side-effects (ces effets touchent moins de 1 personne sur 10) | Que puis-je faire si je ressens cela ? |
Feeling flushed, swollen feet or ankles, chest pain | If any of these symptoms continue or cause you concern, speak with your doctor |
Sensation de vertige | If this happens, sit down for a while until you feel better. Do not drive and do not use tools or machines while affected. Do not drink alcohol |
Se sentir malade (nausée) ou être malade (vomissements), diarrhée | Eat simple meals and drink plenty of water to replace lost fluids |
Douleur articulaire ou musculaire | Speak with your doctor about this as soon as possible. It may be an early sign of systemic lupus erythematosus-like syndrome |
Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, veuillez consulter votre médecin ou votre pharmacien pour obtenir des conseils supplémentaires.
How to store hydralazine
Gardez tous les médicaments hors de la vue et de la portée des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Do not keep-out-of date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
What should I do if I accidentally take too much hydralazine?
If you suspect that you or someone else might have taken an overdose of hydralazine, you should go to the accident and emergency department of your local hospital immediately. Remember to take the medicine container with you, even if it is empty.
Why would hydralazine be prescribed for conditions other than high blood pressure?
While primarily used for high blood pressure, hospital doctors sometimes prescribe hydralazine for other heart conditions. If you've been prescribed it for a reason other than high blood pressure, consult your doctor for clarification about your specific treatment.
Can I stop taking hydralazine once my blood pressure improves?
Treatment with hydralazine is usually long-term. You should continue to take the tablets exactly as prescribed unless your doctor advises you otherwise. Do not stop taking it without your doctor's guidance.
Are there any specific activities I should avoid while taking hydralazine?
If you experience dizziness, which can be a common side-effect, you should sit down until you feel better. While affected by dizziness, it's important not to drive, operate tools, or use machinery. You should also avoid drinking alcohol as it can worsen dizziness.
Can hydralazine affect other medicines I'm taking, even non-prescription ones?
Yes, some medicines can interfere with how hydralazine works. This includes specific medicines available without a prescription, such as some anti-inflammatory painkillers, as well as herbal and complementary medicines. Always check with a pharmacist to ensure any new medicine you buy is suitable for you.
Lectures complémentaires et références
- Manufacturer's PIL, Hydralazine Tablets 25 mg and 50 mg; Accord-UK Ltd, The electronic Medicines Compendium. Dated October 2021.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critique

Sid Dajani
Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Article également disponible en Anglais, Allemand, Espagnol, Français, Italien, Portugais, Hindi, Hébreu, Arabe, and Suédois.
Next review due: 11 Jun 2027
12 déc. 2022 | Dernière version

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