Hydromorphone pour la douleur cancéreuse
Palladone
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 24 fév 2023
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This medicine is an opioid painkiller. There is a serious risk of addiction when taking this medicine, especially if used long-term. The Medicines and Healthcare products Regulatory Agency (MHRA) has issued new guidance for people prescribed an opioid painkiller. If you have any questions or concerns about taking opioids safely please speak with your doctor or a pharmacist.
Hydromorphone eases severe pain associated with cancer.
The capsules can be swallowed whole with a drink of water, or opened and the contents sprinkled on to some soft food such as yoghurt.
The most common side-effects are constipation, drowsiness and feeling sick (nausea). Your doctor may prescribe medicines for you to take with hydromorphone to help with some of these side-effects.
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About hydromorphone
Type de médicament | Strong opioid painkiller |
Utilisé pour | Pain relief in adults with cancer |
Aussi appelé | Palladone® |
Disponible sous forme de | Capsules, and modified-release capsules |
Opioïdes puissants are medicines used to treat severe pain. Hydromorphone is a type of strong opioid (sometimes called an opiate) used to treat pain caused by le cancer. It works on your nervous system and brain to reduce the amount of pain you feel.
Hydromorphone is taken by mouth as a capsule. There are two types of capsule available: quick-acting capsules (Palladone®) and modified-release capsules (Palladone® SR). Modified-release capsules release the hydromorphone they contain more slowly than the quick-acting capsules do. This provides longer and more even pain relief.
Before taking hydromorphone
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking hydromorphone it is important that your doctor knows:
Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.
Si vous avez des problèmes de foie ou de reins.
If you have prostate problems or any difficulties passing urine.
If you have any breathing problems, such as asthma or chronic obstructive pulmonary disease (COPD).
If you have been told you have low blood pressure (hypotension).
If you have any problems with your thyroid, pancreas, or adrenal glands.
Si vous avez de l'épilepsie.
If you have a problem with your bile duct.
If you have been constipated for more than a week or have an inflammatory bowel problem.
Si vous avez une affection provoquant une faiblesse musculaire, appelée myasthénie grave.
If you have a mental health problem called toxic psychosis.
If you have recently had a severe head injury.
If you have ever been dependent on drugs or alcohol.
Si vous avez déjà eu une réaction allergique à un médicament.
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.
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How to take hydromorphone
Retour au sommaireBefore you start taking the capsules, read the manufacturer's printed information leaflet from inside the pack. The manufacturer's leaflet will give you more information about hydromorphone and a full list of the side-effects which you may experience from taking it.
Take hydromorphone exactly as your doctor tells you to. If you have been prescribed the quick-acting capsules (Palladone®), you will be asked to take a dose every four hours. The modified-release capsules (Palladone® SR) are taken twice a day, 12 hours apart.
There are different strengths of both types of hydromorphone capsule, so each time you collect a prescription check to make sure it is the strength you are expecting.
You can swallow the capsules whole with a drink of water, or alternatively, open them and sprinkle the contents on to some soft food, such as yoghurt. Do not dissolve or chew the contents of the capsule as this may release all the medicine at once and cause side-effects.
You can take hydromorphone before or after food.
If you forget to take a dose, take it as soon as you remember and then continue as before. If it is nearly time for your next dose, leave out the forgotten dose and take the next dose when it is due. Do not take two doses together to make up for a forgotten dose. If you are taking quick-acting capsules do not take more than one dose every four hours.
Tirer le meilleur parti de votre traitement
Retour au sommaireAsk your doctor for advice before drinking alcohol while you are on this medicine. Your doctor may recommend you do not drink alcohol while you are on hydromorphone because it increases the possibility of side-effects such as feeling dizzy and sleepy.
If you are a driver, please be aware that hydromorphone is likely to affect your reactions and ability to drive. It is an offence to drive while your reactions are impaired. Even if your driving ability is not impaired, should you drive, you are advised to carry with you some evidence that the medicine has been prescribed for you - a repeat prescription form or a patient information leaflet from the pack is generally considered suitable.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking hydromorphone as a painkiller.
If you buy any medicines, check with a pharmacist that they are suitable for you to take with hydromorphone. Many other medicines have similar side-effects to hydromorphone, and taking them together will increase the risk of these.
If you are planning a trip abroad, you are advised to carry a letter with you from your doctor to explain that you have been prescribed hydromorphone. This is because hydromorphone is classed as a 'controlled drug' and is subject to certain restrictions.
Continue to take hydromorphone unless your doctor tells you otherwise. Stopping suddenly will cause your pain to return, and it can also cause you to feel agitated, anxious, and sweaty. If you need to stop taking hydromorphone your doctor will prescribe an alternative painkiller for you, or reduce your dose gradually.
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Can hydromorphone cause problems?
Retour au sommaireAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with hydromorphone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Effets secondaires courants hydromorphone side-effects | Que puis-je faire si je ressens cela ? |
Se sentir malade (nausée) ou être malade (vomissements) | Stick to simple meals - avoid rich or spicy foods. Also, try taking your doses after food, as this may help |
Shallow breathing | Let your doctor know about this |
Feeling dizzy, sleepy or drowsy | Si cela se produit, ne conduisez pas et n'utilisez pas d'outils ou de machines. Ne buvez pas d'alcool |
Constipation | Try to eat a well-balanced diet and drink plenty of water each day. If this continues to be a problem, speak with your doctor who may prescribe a laxative for you |
Bouche sèche | Essayez de mâcher du chewing-gum sans sucre ou de sucer des bonbons sans sucre |
Other common side-effects include: feeling confused or disorientated, itching, sweating, mood changes, disturbed sleep, headache, difficulties passing urine, flushing, and rash | Si l'un de ces éléments devient problématique, parlez-en à votre médecin |
Important: people taking opioid medicines, and their family and friends, should be aware of the risk of accidental overdose and know when to seek medical help. The risk is higher if you also take other medicines that make you feel drowsy. Signs you have taken too much medicine include:
Feeling very sleepy or dizzy.
Feeling sick (nausea) or being sick (vomiting).
Difficultés respiratoires.
Loss of consciousness.
If you have taken more morphine than you should or someone else accidentally swallows your medication, call for an ambulance and tell them the name of your medicine.
Si vous ressentez d'autres symptômes que vous pensez être dus à ce médicament, parlez-en à votre médecin ou à votre pharmacien.
How to store hydromorphone
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le site web Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Lectures complémentaires et références
- Manufacturer's PIL, Palladone® 1.3 mg and 2.6 mg capsules; Napp Pharmaceuticals Limited, The electronic Medicines Compendium. Dated July 2020.
- Manufacturer's PIL, Palladone® SR capsules; Napp Pharmaceuticals Limited, The electronic Medicines Compendium. Dated July 2020.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Next review due: 23 Aug 2027
24 fév. 2023 | Dernière version

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