Lapatinib tablets

About lapatinib

Lapatinib is a medicine which is given for the treatment of cancer du sein which has progressed despite other treatment, or which has spread into other areas of your body. It is taken alongside other anti-cancer medicines.

In cancer, certain cells in the body grow and multiply in a way that is 'out of control'. Chemotherapy (anti-cancer) medicines work by inhibiting the way cells grow and increase in number. Lapatinib belongs to a group of anti-cancer medicines known as tyrosine kinase inhibitors. These medicines work by blocking the chemical messengers (called tyrosine kinases) which send signals to cells to grow. This in turn stops cancer cells from growing and spreading.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking lapatinib it is important that your doctor knows:

• Si vous avez une infection ou vous vous sentez particulièrement mal.

• Si vous avez des problèmes avec le fonctionnement de votre foie, ou des problèmes avec le fonctionnement de vos reins.

• If you have a heart condition or if you have been told you have an unusual heart rhythm.

• Si vous êtes enceinte ou si vous allaitez.

• Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.

• Si vous avez déjà eu une réaction allergique à un médicament.

• Before you start the treatment, read any printed information you have been given by your doctor and the printed manufacturer's leaflet from inside the pack of tablets. These will give you more information about lapatinib and will provide a full list of the side-effects which you may experience from taking it.

• Lapatinib will be prescribed for you by a specialist doctor who is experienced in treating your condition. It is important that you take the tablets exactly as you are told to. You will be asked to take one dose of lapatinib each day. The number of tablets that you will be asked to take for each dose will depend upon what other treatment you are having - it will be in the range of 4-6 tablets per dose. The directions for taking the tablets will be printed on the label of the pack to remind you, but should you have any concerns, contact your doctor or hospital clinic for further advice.

• Swallow the tablets with a drink of water.

• Take lapatinib at the same time of day each day, as this will help you to remember to take your doses regularly. You can choose whether to take the tablets before or after meals, but you should continue to take all of your doses in the same way. So, either always take your doses one hour before meals, or always one hour afterwards.

• If you forget to take a dose, make sure you remember to take your next dose when it is due. Do not take two doses on the same day to make up for a forgotten dose.

• Do not drink grapefruit juice while you are on lapatinib. This is because a chemical in grapefruit juice can interfere with the amount of lapatinib in your bloodstream.

• You must try to keep your regular appointments with your doctor or hospital. This is so your doctor can check on your progress. You will need to have regular check-ups during treatment. If at any time you feel short of breath or if you develop a high temperature (fever) or a dry cough, you must let your doctor know about it straightaway so that it can be investigated.

• If you buy or take any other medicines, check with a pharmacist that they are suitable to take alongside lapatinib. You should not take any preparations which contain St John's wort (a herbal remedy used for low moods), as these can reduce the effectiveness of lapatinib.

• Si vous subissez une opération ou un traitement dentaire, informez toujours la personne effectuant le traitement des médicaments que vous prenez.

• It is important that you do not get pregnant while you are taking lapatinib. If relevant, make sure you discuss with your doctor which types of contraception are suitable for you and your partner.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with lapatinib. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

If you experience any other symptoms which you think may be due to the tablets, ask your doctor or pharmacist for advice.

• Gardez tous les médicaments hors de la portée et de la vue des enfants.

• Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.

• Please return any unused or unwanted tablets to your clinic or pharmacy to destroy.