Comprimés de médroxyprogestérone
Provera
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 4 Mar 2025
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Your dose of medroxyprogesterone will depend on what you are being treated for. Your doctor or pharmacist will tell you how many tablets to take and how often to take them.
Any side-effects are usually mild but can include feeling sick (nausea), irregular menstrual bleeding, weight gain and headache.
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About medroxyprogesterone
Type de médicament | Un progestatif (hormone féminine) |
Utilisé pour | Irregular or missed periods, endometriosis, and some cancers |
Aussi appelé | Provera® |
Disponible sous forme de | Comprimés |
Medroxyprogesterone belongs to a group of medicines called progestogens, which are female hormones.
When it is prescribed to help problems such as règles abondantes, painful, irregular or missed periods, it works by replacing or supplementing the naturally produced female sex hormone called progesterone.
Medroxyprogesterone is also used for endometriosis. Endometriosis is a condition where tissue that normally lines the inside of your womb (uterus) is found elsewhere in your body, often in the pelvic area or tummy (abdomen). The cells in this tissue need oestrogen (another female sex hormone) to grow and survive. Medroxyprogesterone reduces the effect of oestrogen on these cells which causes them to 'shrink'. This means the patches of endometriosis also shrink.
Medroxyprogesterone is also prescribed (although at higher doses than in the conditions mentioned above) to help treat some cancers, particularly cancer de l'endomètre.
Medroxyprogesterone is also available as an injection to prevent pregnancy, and as tablets (in combination with an oestrogen) for hormone replacement therapy (HRT) during the menopause. There are other medicine leaflets available which will give you more information about medroxyprogesterone when it is used for these reasons. See the separate leaflets called Injection de médroxyprogestérone pour la contraception et Œstrogène et progestatif pour THS.
Before taking medroxyprogesterone
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking medroxyprogesterone tablets, it is important that your doctor knows:
Si vous êtes enceinte ou si vous allaitez.
Si vous avez un problème avec vos artères, appelé maladie artérielle.
Si vous avez une maladie cardiaque.
If you have any of the following conditions: migraines, asthma, epilepsy, diabetes, or high blood pressure.
Si vous avez des saignements vaginaux autres que votre règle mensuelle habituelle.
If you have ever had a blood clot in your legs or lungs.
If you have had any problems with the way your liver works, or if you have any problems with the way your kidneys work.
If you have ever had depression.
If you have ever had breast cancer, or a cancer that you have been told is dependent on a sex hormone (unless this is why you have been prescribed medroxyprogesterone).
Si vous avez un trouble sanguin héréditaire rare appelé porphyrie.
Si vous avez déjà eu une réaction allergique à un médicament.
Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.
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How to take medroxyprogesterone
Retour au sommaireBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack of tablets. It will give you more information about medroxyprogesterone and it will also provide you with a full list of the side-effects which you could experience from taking it.
Take medroxyprogesterone tablets exactly as your doctor tells you to. There are several strengths of tablets, so it is a good idea to make sure you have been given the same strength each time you collect a fresh supply. If you are unsure about this, ask your pharmacist to check the strength for you.
Your dose will depend on what you are being treated for. Your doctor will tell you how many tablets to take for each dose, and how often to take them. You may be asked to take the tablets every day, or only on certain days of your monthly cycle. The dose will also be printed on the label of the pack of tablets to remind you about what the doctor said to you but, if you are still unclear about how to take the tablets, you should ask your pharmacist to explain it to you again.
You can take medroxyprogesterone tablets either before or after meals. It is advisable to swallow the tablets with a drink of water.
Try to take your doses at the same time of day each day, as this will help you to remember to take medroxyprogesterone regularly. If you forget to take a dose, take it as soon as you remember (unless it is nearly time for your next dose, in which case leave out the missed dose and take the next dose as normal). Do not take two doses together to make up for a forgotten dose.
Tirer le meilleur parti de votre traitement
Retour au sommaireTry to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Also, remember to keep any routine appointments for breast screening and cervical smear tests.
These tablets are not for preventing pregnancy. If you need contraception you should discuss this with your doctor. It is important that you do not become pregnant whilst taking medroxyprogesterone as this treatment may harm your unborn baby.
If you have diabetes you may need to check your blood glucose more frequently, as the tablets can affect the levels of sugar in your blood. Your doctor will advise you about this.
It is best to avoid smoking and drinking too much alcohol while taking medroxyprogesterone. If you are a smoker and you would like advice on how to quit, speak with your doctor or pharmacist.
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Can medroxyprogesterone tablets cause problems?
Retour au sommaireAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with medroxyprogesterone tablets. You will find a full list in the manufacturer's information leaflet that has been given to you. The unwanted effects may improve as your body adjusts to the new medicine, but speak with your doctor, nurse or pharmacist if any of the following continue or become troublesome.
Medroxyprogesterone side-effects | Que puis-je faire si je ressens cela ? |
Maux de tête | Demandez à votre pharmacien de vous recommander un antidouleur approprié. Si le mal de tête persiste ou est inhabituellement sévère, consultez votre médecin dès que possible |
Sensation de malaise (nausée) | Mangez des repas simples (évitez les aliments riches ou épicés) |
Irregular periods, breast tenderness, weight changes, feeling dizzy or tired, difficulty sleeping, changes in sexual desire, mood changes, skin rash, acne-like spots, changes in hair growth, swollen feet and ankles (due to fluid retention) | Parlez à votre médecin si l'un de ces symptômes devient gênant |
Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.
How to store medroxyprogesterone
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous immédiatement au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
If you buy any medicines, always check with a pharmacist that they are suitable to take with your prescribed medicines.
If you are due to have an operation, please tell the person carrying out the treatment which medicines you are taking.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le site web Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Lectures complémentaires et références
- Manufacturer's PIL, Provera® 2.5 mg, 5 mg and 10 mg Tablets; Pfizer Limited, The electronic Medicines Compendium. Dated February 2024.
- Manufacturer's PIL, Provera® 100 mg, 200 mg and 400 mg Tablets; Pfizer Limited, The electronic Medicines Compendium. Dated February 2024.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Next review due: 3 Mar 2028
4 Mar 2025 | Dernière version

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