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Prucalopride pour la constipation

Resolor

Take one tablet daily.

The most common side-effects are headache, feeling sick (nausea) and diarrhoea.

At a glance

  • Prucalopride is a medicine used to treat long-term constipation in adults.

  • It is typically prescribed when other treatments like lifestyle changes and laxatives have not worked.

  • Prucalopride works by increasing the movement of your bowels, making stools easier to pass.

  • You usually take one tablet once a day, with or without food.

  • Common side-effects include headache, feeling sick, tummy pain, and diarrhoea.

  • Contact your doctor if you are pregnant, have other bowel conditions, or have heart, liver, or kidney problems.

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About prucalopride

Type de médicament

Selective serotonin 5HT4-receptor agonist

Utilisé pour

Constipation

Aussi appelé

Resolor®

Disponible sous forme de

Comprimés

Constipation chez les adultes is a common problem. It means either going to the toilet less often than usual to empty the bowels, or passing hard or painful stools when you do go. It can be caused by not eating enough fibre or not drinking enough fluids, or a lack of exercise or movement (such as being ill in bed). It can also be a side-effect of certain medicines (such as some painkillers), or related to an underlying medical condition. In many cases, the cause is not clear.

Prucalopride works on the muscle wall of the bowels. It increases the movement of the bowels, making stools easier to pass. It can be helpful for people for whom constipation remains a problem despite having made changes to lifestyle and diet, and despite having tried a number of different laxatives.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking prucalopride it is important that your doctor knows:

  • Si vous êtes enceinte, essayez d'avoir un bébé, ou allaitez.

  • Si vous êtes tellement constipé que vous pensez avoir une obstruction.

  • If you have any other bowel condition (such as Crohn's disease, ulcerative colitis or toxic megacolon).

  • If you have a heart condition or have been told that you have an unusual heart rhythm.

  • Si vous avez des problèmes avec le fonctionnement de votre foie ou de vos reins.

  • Si vous avez déjà eu une réaction allergique à un médicament.

  • Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.

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  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about prucalopride and will provide you with a full list of the side-effects which you may experience from taking it.

  • Take prucalopride tablets exactly as your doctor tells you to. It is usual to be prescribed one (2 mg) tablet to take once daily. You may be given a lower-strength tablet if you are over 65 years old, or if you have any problems with your liver or kidneys.

  • Swallow the tablet with a drink of water. You can take the tablet at a time of day to suit you. It is recommended that you take your doses at the same time of day each day, as doing this can help you to remember to take your doses regularly. You can take prucalopride tablets before or after food.

  • If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, leave out the forgotten dose and take the dose that is due. Do not take two tablets at the same time to make up for a missed dose.

  • Remember to keep any regular appointments with your doctor. This is so your doctor can check on your progress.

  • A healthy diet containing fibre (wholegrain breads and cereals, bran, fruit and green leafy vegetables) with several glasses of water each day and daily exercise are important in maintaining healthy bowel function.

  • You can read our leaflet called Fibre and Fibre Supplements for advice on ways to increase the amount of fibre in your diet.

  • You should avoid getting pregnant while you are taking prucalopride. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with prucalopride. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common prucalopride side-effects (these affect more than 1 in 10 people)


Que puis-je faire si je ressens cela ?

Maux de tête

Buvez beaucoup d'eau et demandez à votre pharmacien de vous recommander un antidouleur approprié. Si les maux de tête persistent, informez votre médecin

Sensation de malaise (nausée), douleur au ventre (abdominale)

This usually passes within a few days. In the meantime eat simple meals - avoid rich or spicy foods

Diarrhée

Buvez beaucoup d'eau

Common prucalopride side-effects

(ces effets touchent moins de 1 personne sur 10)

Que puis-je faire si je ressens cela ?

Se sentir étourdi ou fatigué

Do not drive and do not use tools or machines while you feel dizzy

Indigestion, upset stomach, passing urine frequently, rectal bleeding

Si cela pose problème, parlez-en à votre médecin

Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.

  • Gardez tous les médicaments hors de la portée et de la vue des enfants.

  • Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.

Informations importantes sur tous les médicaments

Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.

Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.

Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.

If you buy any medicines, always check with a pharmacist that they are suitable for you to take with your other medicines.

Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.

Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.

Signaler les effets secondaires d'un médicament ou d'un vaccin

Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Yellow Card website.

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Questions fréquemment posées

How quickly should I expect prucalopride to work once I start taking it?

The article states that prucalopride increases the movement of the bowels, making stools easier to pass. While it doesn't specify an exact timeframe, the unwanted effects often improve as your body adjusts to the new medicine, which suggests a period of adjustment in the initial days of treatment.

What should I do if I am already taking other medications for constipation or other conditions?

Before you start taking prucalopride, it's very important to inform your doctor about any other medicines you are taking. This includes both prescription medicines and those you can buy without a prescription, as well as herbal and complementary medicines. Your doctor needs this information to ensure prucalopride is suitable for you.

Is there a specific time of day I should take prucalopride?

You can take prucalopride at a time of day that suits you, whether before or after food. However, it is recommended to take your doses at the same time each day. This routine can help you remember to take your medicine regularly.

How long will I need to take prucalopride?

The article does not specify a duration for taking prucalopride. It mentions that you should keep any regular appointments with your doctor so they can check on your progress, suggesting treatment length will be decided by your doctor based on your individual needs and response.

What lifestyle changes are important to support my treatment with prucalopride?

While taking prucalopride, it's still important to maintain a healthy lifestyle to support healthy bowel function. This includes eating a diet rich in fibre (like wholegrain breads, cereals, bran, fruit, and green leafy vegetables), drinking several glasses of water daily, and getting daily exercise.

Can I stop taking prucalopride once my constipation improves?

The article advises to keep regular appointments with your doctor so they can check your progress. It does not provide guidance on stopping the medication, implying that any decision about ending treatment should be made in consultation with your doctor.

What if I experience unusual symptoms that are not listed as common side-effects?

If you experience any other symptoms that you believe might be due to prucalopride tablets, you should speak with your doctor or pharmacist for further advice. The manufacturer's leaflet supplied with your medicine will also contain a full list of possible side-effects.

Lectures complémentaires et références

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About the authorView full bio

Author image

Michael Stewart, MRPharmS

Medicine Leaflet Review Manager – Contractor, Pharmacist

BPharm (Hons), MRPharmS

Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.

About the reviewer

Author image

Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

Historique de l'article

Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.

  • Prochaine révision prévue : 18 sept. 2026
  • 19 sept. 2023 | Dernière version

    Dernière mise à jour par

    Michael Stewart, MRPharmS

    Revu par

    Sid Dajani
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